This comprehensive guide explored the essential steps to secure residency programs in the USA after USMLE’s success. Beginning with an introduction to the significance of residency programs, we navigated through the structure and components of the USMLE, emphasizing the importance of thorough preparation. We highlighted the role of USMLE scores in residency matching and outlined the next steps for post-USMLE success, including research, application, and interview preparation. With dedication and strategic planning, aspiring physicians can open doors for a prosperous medical career in the US.